Purpose

The purpose of this study is to evaluate the safety and effectiveness of the PROMUS Element™ Everolimus-Eluting Coronary Stent System for the treatment of patients with up to 2 de novo atherosclerotic coronary artery lesions.

Eligibility

Criteria

Inclusion Criteria:

• Patient must be at least 18 years of age
• Patient (or legal guardian) understands study requirements and treatment procedures and provides written informed consent      before any study-specific tests or procedures are performed
• For patients less than 20 years of age enrolled at a Japanese site, patient and patient's legal representative must provide    written informed consent before any study-specific tests or procedures are performed
• Patient is eligible for percutaneous coronary intervention (PCI)
• Patient has documented stable angina pectoris (Canadian Cardiovascular Society [CCS] Classification 1, 2, 3, or 4) or    documented silent ischemia; or unstable angina pectoris (Braunwald Class IB C, IIB C, or IIIB C)
• Patient is an acceptable candidate for coronary artery bypass grafting (CABG)
• Patient has a left ventricular ejection fraction (LVEF) >=30% as measured within 30 days prior to enrollment
• Patient is willing to comply with all protocol-required follow-up evaluations.

Angiographic Inclusion Criteria (visual estimate):

• Target lesion must be a de novo lesion located in a native coronary artery with a visually estimated reference vessel diameter (RVD) as follows.
  • >=2.50 mm and <=4.25 mm for the RCT (WH selection criteria)
  • >=2.25 mm and <2.50 mm for non-randomized SV subtrial (SV selection criteria)
  • >=2.50 mm and <=4.25 mm for non-randomized LL subtrial (LL selection criteria)
• Target lesion length must measure (by visual estimate) as follows.
  • <=24 mm for the RCT (WH selection criteria)
    
  • <=28 mm for non-randomized SV subtrial (SV selection criteria
    
  • >24 mm and <=34 mm for non-randomized LL subtrial (LL selection criteria)
• Target lesion must be in a major coronary artery or branch with visually estimated stenosis >=50% and <100% with Thrombolysis in Myocardial Infarction (TIMI) flow >1.

• Patient has clinical symptoms and/or electrocardiogram (ECG) changes consistent with acute MI
• Patient has had a known diagnosis of recent MI (ie, within 30 days prior to index procedure) and has elevated enzymes at time of index procedure as follows:
  • Patients are excluded if any of the following criteria are met at time of the index procedure.
    
  • If CK MB >2× upper limit of normal (ULN), the patient is excluded regardless of CK Total.
  • If CK MB is 1 2× ULN, the patient is excluded if the CK Total is >2× ULN.
  • If CK Total/CK MB are not used and Troponin is, patients are excluded if the following criterion is met at time of index procedure.
  • Troponin >1× ULN with at least one of the following.
  • Patient has ischemic symptoms and ECG changes indicative of ongoing ischemia (eg, >1 mm ST segment elevation or depression in consecutive leads or new left bundle branch block [LBBB])
  • Development of pathological Q waves in the ECG; or
  • Imaging evidence of new loss of viable myocardium or new regional wall motion abnormality.

• Patient has received an organ transplant or is on a waiting list for an organ transplant
• Patient is receiving or scheduled to receive chemotherapy within 30 days before or after index procedure
• Patient is receiving oral or intravenous immunosuppressive therapy (ie, inhaled steroids are not excluded) or has known life-limiting immunosuppressive or autoimmune disease (eg, human immunodeficiency virus, systemic lupus erythematosus, but not including diabetes mellitus)
• Patient is receiving chronic (>=72 hours) anticoagulation therapy (eg, heparin, coumadin) for indications other than acute coronary syndrome
• Patient has platelet count <100,000 cells/mm3 or >700,000 cells/mm3
• Patient has white blood cell (WBC) count <3,000 cells/mm3
• Patient has documented or suspected liver disease, including laboratory evidence of hepatitis
• Patient is on dialysis or has known renal insufficiency (ie, estimated creatinine clearance <50 ml/min by the Cockcroft Gault formula, or [(140-age)*lean body weight (in kg)]/[plasma creatinine (mg/dl)*72])
• Patient has history of bleeding diathesis or coagulopathy or will refuse blood transfusions
• Patient has had a cerebrovascular accident (CVA) or transient ischemic attack (TIA) within past 6 months, or has any permanent neurologic defect that may cause non-compliance with the protocol
• Target vessel(s) or side branch has been treated with any type of PCI (eg, balloon angioplasty, stent, cutting balloon, atherectomy) within 12 months prior to index procedure
• Target vessel(s) has been treated within 10 mm proximal or distal to target lesion (by visual estimate) with any type of PCI (eg, balloon angioplasty, stent, cutting balloon, atherectomy) at any time prior to index procedure
• Non-target vessel or side branch has been treated with any type of PCI (eg, balloon angioplasty, stent, cutting balloon, atherectomy) within 24 hours prior to index procedure
• Planned or actual target vessel(s) treatment with an unapproved device, directional or rotational coronary atherectomy, laser, cutting balloon, or transluminal extraction catheter immediately prior to stent placement
• Planned PCI or CABG after index procedure
• Patient previously treated at any time with coronary intravascular brachytherapy
• Patient has a known allergy to the study stent system or protocol-required concomitant medications (eg, stainless steel, platinum, cobalt, chromium, nickel, tungsten, acrylic, fluoropolymers, everolimus, thienopyridines, aspirin, contrast) that cannot be adequately premedicated
• Patient has active peptic ulcer or active gastrointestinal (GI) bleeding
• Patient has one of the following.
  • Other serious medical illness (eg, cancer, congestive heart failure) that may reduce life expectancy to less than 24 months
  • Current problems with substance abuse (eg, alcohol, cocaine, heroin, etc.)
  • Planned procedure that may cause non-compliance with protocol or confound data interpretation
• Patient is participating in another investigational drug or device clinical trial that has not reached its primary endpoint
• Patient intends to participate in another investigational drug or device clinical trial within 12 months after index procedure
• Known intention to procreate within 12 months after index procedure
• Female with positive pregnancy test within 7 days prior to index procedure (a pregnancy test must be performed in women of child-bearing potential prior to enrollment), or lactating
• Patient has more than 2 target lesions, or more than 1 target lesion and 1 non-target lesion, identified during screening for intervention

• Target lesion meets any of the following criteria:
• Aorto-ostial location (ie, lesion located within 5 mm of ostium by visual estimate)
• Left main location
• Located within 5 mm of origin of the left anterior descending (LAD) coronary artery or left circumflex (LCX) coronary artery by visual estimate
• Located within a saphenous vein graft or arterial graft
• Can only be accessed via a saphenous vein graft or arterial graft
• Involves a side branch >=2.0 mm in diameter by visual estimate
• Involves a clinically significant side branch <2.0 mm in diameter by visual estimate that has a clinically significant stenosis at the ostium
• TIMI flow 0 (total occlusion) or TIMI flow 1 prior to wire crossing
• Excessive tortuosity proximal to or within the lesion
• Extreme angulation proximal to or within the lesion
• Target lesion and/or target vessel proximal to the target lesion is moderately to severely calcified by visual estimate
• Restenotic from previous intervention
• Thrombus, or possible thrombus, present in target vessel
• Patient has an additional clinically significant lesion(s) in target vessel for which an intervention within 12 months after the index procedure is likely to be required

Contacts
Physicians:
Ameer Kabour, MD
Tarif Kanaan, MD

Coordinators:
Michelle Hickam, BSN
Julie Neidhardt, BSN
Brenda Hoagland, RN, CCRC

Please contact us at 419-251-4919 for more information about this study.

 

Click here for Printable copy of trial.