Purpose

The purpose of this study is to determine the efficacy and safety of I.V. SLV320 in acute heart failure patients with renal dysfunction.

Eligibility

Criteria

Inclusion Criteria:

• Renal dysfunction defined as estimated eGFR of 20-80 mL/min;
• History of systolic or diastolic chronic heart failure of at least 14 days duration for which loop diuretic therapy has been prescribed;
• Clinical evidence for volume overload;
• BNP > 500 pg/mL or NT-pro-BNP > 2000 pg/mL;
• Hospitalization

• Have low output syndrome, defined as having the need for treatment with I.V. inotropes or vasopressors;
• Need mechanical ventilation
• Have significant stenotic valvular disease (severe aortic or mitral stenosis);
• Have myocardial infarction or hemodynamically destabilizing significant arrythmias (ventricular tachycardia, bradyarrythmias with slow ventricular rate [<45 bpm] or atrial fibrillation/flutter with a rapid ventricular response of >120 bpm), or electrocardiographic evidence of 2nd degree heart block (Mobitz Type II) or 3rd degree AV-block in the absence of a pacemaker, within 30 days of screening;
• Have acute myocarditis or hypertrophic obstructive, restrictive, or constrictive cardiomyopathy

Contacts

Physicians:
Ameer Kabour, MD
Mohammad Alkhateeb, MD
Raza Hashmi, MD
Tarif Kanaan, MD